Which word does not have a similar meaning to "energize"?

The word that does not have a similar meaning to "energize" is "enervate." To energize means to give energy or vigor to something; it conveys a sense of revitalization or activation. In contrast, "enervate" means to weaken or drain energy, which is the opposite of energizing.

On the other hand, the words "rejuvenate," "strengthen," and "uplift" all relate to enhancing vitality, improving strength, or raising one’s mood, which align with the concept of energizing. Therefore, "enervate" distinctly stands out as having an opposing meaning to "energize."